Gianni Liti, 15.3.2017

SLOVENSKO GENETSKO DRUŠTVO

vabi na društveno predavanje

 

Gianni Liti

Institute for Research on Cancer and Ageing, Nica, Francija

 

YEAST POPULATION GENOMICS:

ORIGIN AND EVOLUTION OF A CLASSIC MODEL ORGANISM

 

 

Predavanje bo v sredo, 15. marca 2017, ob 15:30

v predavalnici B2 na Oddelku za biologijo BF UL, Večna pot 111, Ljubljana

 

POVZETEK PREDAVANJA

The baker’s yeast Saccharomyces cerevisiae has had a long association with human activity, leading to the idea that its use in fermentation lead to its domestication. However, recent studies revealed that S. cerevisiae has a rather ubiquitous distribution in the wild, not limited to human-associated environments, showing that its history goes far beyond its association with humans. In the past decade, we applied population-level sequencing to thousands of S. cerevisiae strains to further illuminate the population structure and the impact of human activity. Many breeds associated to specific human process (e.g. wine, sake, beer, bioethanol) have specific genomic signatures likely driven by adaptation to industrial environments. In parallel, we discovered many wild lineages and detected substantial genomic differences when compared with the human associated strains. Interestingly, genome analysis of highly diverged wild lineages that predate domestication is consistent with South East Asia as the geographic origin of S. cerevisiae. We further explore this natural variation by generating synthetic population derived by genetic crosses and pioneered these microbial outbred populations in experimental evolution analysis.